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| 货号 | RC0277 |
| 名称 | 二氢杨梅素 |
| 说明书 | |
| CAS号 | 27200-12-0 |
| 分子式 | C15H12O8 |
| 分子量 | 320.25 |
| 产品描述 | |
| 描述 | Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. |
| 纯度 | 98% |
| 储存/保存方法 | RT |
| 基本信息 | |
| 别名 | 二氢杨梅素；Ampelopsin；Ampeloptin |
| 外观 | white to beige powder |
| 可溶性/溶解性 | DMSO : ≥ 100 mg/mL (312.26 mM) |
| 生物活性 | |
| 靶点 | GABAA receptor |
| In vitro(体外研究) | Dihydromyricetin shows antioxidant activity as an effective scavenger of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). It also inhibits the increase of lipid peroxidation (LPO) values in linolei acid system catalyzed by FeSO4-edetic acid. DHM (1 μM) as a novel anti-alcohol intoxication medication antagonizes both acute EtOH-induced potentiation of GABA(A)Rs and EtOH exposure/withdrawal-induced GABA(A)R plasticity and increases in GABA(A)R alpha4 subunit expression in hippocampus and cultured neurons. |
| In vivo(体内研究) | Dihydromyricetin (1 mg/kg, i.p.) counteracts acute alcohol (EtOH) intoxication, and also withdrawals signs in rats including tolerance, increased anxiety, and seizure susceptibity. LD50: Mice 1.41g/kg (i.p.) |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 | |
